Apolipoprotein B100

ApoB100; Apoprotein B100; Hypercholesterolemia - apolipoprotein B100

Considerations

Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown.

Definition

Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low density lipoprotein (LDL).

Mutations (changes) in apoB100 can cause a condition called familial hypercholesterolemia. This is a form of high cholesterol that is passed down in families (inherited).

This article discusses the test used to measure the level of apoB100 in the blood.

How the Test is Performed

A blood sample is needed.

How the Test will Feel

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

How to Prepare for the Test

Your health care provider may tell you not to eat or drink anything for 4 to 6 hours before the test.

Normal Results

The normal range is about 50 to 150 mg/dL.

Normal value ranges may vary slightly among different laboratories. Some laboratories use different measurements or may test different specimens. Talk to your provider about the meaning of your specific test results.

Risks

Risks linked with having blood drawn are slight, but may include:

  • Excessive bleeding
  • Fainting or feeling lightheaded
  • Hematoma (blood buildup under the skin)
  • Infection (a slight risk any time the skin is broken)
  • Multiple punctures to locate veins
What Abnormal Results Mean

An abnormal result may mean you have high lipid (fat) levels in your blood. A medical term for this is hyperlipidemia.

Other disorders that may be associated with high apoB100 levels include atherosclerotic vascular disease such as angina pectoris (chest pain that occurs with activity or stress) and heart attack.

Why the Test is Performed

Most often, this test is done to help determine the cause or specific type of high blood cholesterol. It is not clear whether the information helps improve treatment. Because of this, most health insurance companies DO NOT pay for the test. If you DO NOT have a diagnosis of high cholesterol or heart disease, this test may not be recommended for you.

Fazio S, Linton MF. Regulation and clearance of apolipoprotein B-containing lipoproteins. In: Ballantyne CM, ed. Clinical Lipidology: A Companion to Braunwald's Heart Disease. 2nd ed. Philadelphia, PA: Elsevier; 2015:chap 2.

Genest J, Libby P. Lipoprotein disorders and cardiovascular disease. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier Saunders; 2018:chap 48.

Semenkovich, CF. Disorders of lipid metabolism. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 206.

Review Date: 5/16/2018
Reviewed By: Michael A. Chen, MD, PhD, Associate Professor of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington Medical School, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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